For women with systemic symptoms such as hot flashes, night sweats, sleep disruption, mood changes, brain fog, and fatigue, systemic estrogen therapy is the foundation. We prefer transdermal delivery (patches, gels) for most patients because it avoids first pass liver metabolism and carries a lower risk profile for clotting and metabolic effects. For women with an intact uterus, progesterone is added for endometrial protection. This is a safety requirement, not optional, and is not based on progesterone lab levels.
The majority of women in our program stabilize on estrogen and progesterone and feel significantly better. Libido often improves with estrogen alone.
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